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However the quality and comprehensiveness of the samples and method improvements over time may also impact on these findings.
Nonetheless, we acknowledge that our biomarker, venous whole blood samples, and method of exposure assessment differ from each of the previously reported studies.
The discrepancy between our data and Wong et al's data would be most likely due to the different samples and method used.
Although the number of differently expressed genes that is detected in an experiment is highly sensitive to the experimental design, replication scheme, pooling of samples, and method of statistical analysis, these findings suggest that divergence in brain gene expression may be greater when individuals are separated into two very distinct behavioral classes.
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Details of laboratory methods used in processing archived tissue samples and methods of quality control.
The difference between rates in different studies may relate to the samples and methods used.
A summary of the research questions, samples and methods is presented in Figure 1.
However, it is generally accepted that differences benefit from verification with independent samples and methods.
We collected information on the study population, study design, case definitions, laboratory samples and methods and identified pathogens.
Narrative synthesis allows the examination of studies that are highly heterogeneous in their research questions, samples and methods.
Moreover, the sample substrates, sample thicknesses, and methods of sample preparation can be similar for both methods.
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