We believe that the identification of a single rare deletion of a gene or part of a gene or a truncating variant is not sufficient evidence that the gene abnormality is pathogenic and without the assistance of parental samples and extended pedigrees this can be difficult to interpret.
A doubling of serum creatinine level generally is a late event in chronic kidney disease (CKD); thus, there is great interest in considering alternative end points for clinical trials to shorten their duration, reduce sample size, and extend their conduct to patients with earlier stages of CKD.
In conclusion, our findings, representing the everyday practice pattern of Danish ophthalmologists, and based on a large population-based sample, corroborate and extend the existing evidence of diabetes mellitus as a risk factor for medical glaucoma treatment.
A total 150 and 845 data points (for each orientation) for input variables were generated using Hyper Cubic Sampling and extended FAST methods for uncertainty and sensitivity analyses respectively.
This second assembly step reduces redundancy between the assemblies from each sample and extends any partial transcripts contained within individual sample assemblies.
Although we could not reconstruct the exact study design, we based our analysis on a large sample and extended our investigations to several independent cohorts.
The main drawback with these disk-based approaches is that they are aimed at counting k-mers in a single sample and extending them over to multiple samples is non-trivial.
In total, five transverse 5 μm sections parallel to the midsagittal plane were cut at 2 mm intervals and stained with hematoxylin/eosin and Safranin O. Overall, a total width of 10 mm was thus covered starting from the central point of the sample and extending 10 mm into the sample periphery.
However, the pore size distributions for other samples are broad and extend to lager size, although the dominant pore diameter is about 2 nm for other samples (Fig. 7).
MELK expression is significantly upregulated in the breast cancer samples, confirming and extending the independent observations made by other laboratories on unmatched breast cancer tissue and normal tissue [ 22, 23].
