Lubchenco was speaking from the deck of the NOAA research vessel Thomas Jefferson, which, 43 days into BP's oil-spill disaster, is off on a 10-day effort to take water samples and advanced measurements beneath the surface.
The combination of our normal CSF samples, including a set of serial CSF samples, and advanced technology contribute to the uniqueness and value of our study.
The other two lines are microbeam facilities; one is designed for nuclear microscopy of biomedical samples and advanced materials, where relatively high currents (>50 pA) are required, and the other for proton beam micromachining (PBM) and materials modification, where lower currents can be utilised.
This is an important point, especially in the light of a report by Dupont Jensen et al (2011), showing discordances between PIK3CA mutations in primary breast tumours and their metastases, which might influence the results of studies based on retrospective sample collection and advanced treatment lines.
Though not significant, we found slight increases in students' accurate knowledge elements (key concepts, CINS scores) between the samples of majors and advanced majors using both interview data and ACORNS data (CINS: t47 = 1.33, p > 0.05; ACORNS key concept: t53 = 0.63, p > 0.05; Interviews key concept: t53 = 1.31, p > 0.05).
Collection of repeated tumor biopsy samples and advances in single-cell profiling technologies will help generate more accurate metrics of genomic instability.
Investigations using larger samples and advances in both genotyping and analytical methodologies will be crucial to success in unraveling the causal pathway for this common and serious cause of healthcare-associated infection.
The three candidate miRNAs; miR-34a, miR-150, and miR-923 were analysed in a validation cohort of 97 independent plasma samples comprising 20 normal, 20 polyp, 20 adenoma samples, 23 early stage cancer samples, and 14 advanced cancer samples (see Table 3).> -wrap-foot> Bold text denotes significant comparisons.
The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples.
Our results were consistent in two different population-based samples of different origin and advanced age.
A further evaluation of a larger panel of patient samples including early neoplasia and advanced metastatic stages is needed where a special focus will be placed on immune cell infiltration, interferon concentration and an interferon-responsive gene signature.
