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A pure nDNA sample would reduce the amount of chloroplast and mitochondrial reads therefore increasing the coverage of the nuclear genome.
We hypothesized that the restriction to a smaller well-defined sample would reduce heterogeneity and improve the power of detecting linkage.
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Each tumor sample may have its own specific regulatory program, and therefore pooling different tumor samples would reduce the ability of REACTIN to detect the differential regulatory programs (presumably because no single program is shared amongst all these samples).
If phylogenetic conflict was the result of poor taxonomic sampling and/or a poor choice of outgroup, expanding taxon and outgroup sampling would reduce the conflict between gene trees.
Specifically, researchers aiming to deduce trends in the PCB exposure experienced by a population over time should consider sampling females 17 years of age or > 60 years of age, because such sampling would reduce the variability caused by factors other than dietary contamination.
Focussed COX2 sequencing with larger within-site sample sizes would reduce sampling variance and could provide further insight into the importance of this mutation.
Assuming an intra-person correlation of 0.2, the sample size would reduce by approximately 1/3 and if 20% dropout is also assumed, a total sample size of ~3130 data points would be collected, large enough to allow modelling of the associations between physical and mental illness as specified in the hypotheses.
Using a small sample size would reduce the power of the test.
It was concluded, however, that a large sample size would reduce the effect size of this (Caswell and Manning, 2009); hence, this possible error is unlikely to have a large effect in our study.
All 1,568 pORFs were categorized by functional annotation as opposed to a gene-by-gene comparison, with the assumption that a larger sample size would reduce the discrepancies between protein and RNA abundances.
The objective of this study was to design and test a prototype automatic trim sampler that would reduce the resource demands of, and result in more representative sampling than, N60.
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