A split-sample validation on 60 independent basins (not included in the training) indicates that simultaneous predictions of initiation process and response types are at least 78% accurate.
Coefficient of determination, (relative) root mean squared error and Nash-Sutcliffe efficiency were used to evaluate forecasts, the model selection was based on an out-of-sample validation on rolling basis.
The acute myocardial infarction and pneumonia readmission-risk models performed well on a random sample validation cohort (AUC range 0.73 to 0.76) but less well on a historical validation cohort (AUC 0.66 for both).
It may be that this is due to LA policies or a quirk of the sample, and validation on a different sample would provide contrary evidence.
When the models developed in the derivation cohort were tested on the random sample validation cohort, the AUCs ranged from 0.63 to 0.76 (Additional file 1) and showed no evidence of a lack-of-fit.
70, 5695 5697] showed lower generic fecal diagnostic sensitivity, at 55%, than BacUni-UCD, at 100%, in detecting fecal markers on the 42-sample validation set.
All analyses aiming to assess the psychometric properties of the questionnaire were done on the validation sample with the discharge and follow-up data pooled together, and then replicated on the full sample (construction + validation) on the discharge and follow-up data separately, to confirm that the structure held for both IBHQ versions.
Dependent on the selection criteria described above, between one and 17 variants per sample were selected for validation (on average, 3.6 variants per sample; Supp. Tables S3A and S3B), leading to a total of 359 validated variants in the cohort of 100 samples.
There was no association between rs11683487 and the risk of OC in the samples used for validation on their own (Pdominant=0.92; OR=1.01 (0.85–1.20)).
Sequencing artifacts (i.e. small regions of compression and/or unusual peak morphology) due to region-specific sequence motifs were reproducibly observed in both the positive control samples sequenced during protocol development and the developmental validation on population samples.
RORA differential expression was not validated (p-value > 0.05) and, consequently, we did not perform biological validation on this sample.
