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It is possible that a bootstrap would have yielded different results, but the simulation is consistent with the way data like ours are used; we will seek to replicate these results in another sample (using simulation) in future work.
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In another study Nancarrow et al visualize the expected pattern of allele frequencies depending on varying proportions of normal cells in the tumor sample using simulations [11].
An asymptotic distribution of the test statistic is derived and the test performance in finite samples is studied using simulation.
A second test simulates variants in data from the same sample using a simulation tool, Bamsurgeon [ 24], to test detection and correct annotation of a range of variants that would typically be treated as clinically significant.
Moreover, a test of sensitivity of model choice to sample size was performed using simulation methods.
Bailey et al (2006) concluded that this was not possible and that CR can actually induce bias in ortholog sampling; they also showed using simulation studies that different conditioning genomes can result in different trees being derived for the same dataset.
The input output samples, obtained using simulations in Matlab Simulink, were used for the extensive training of the neural network.
When proxy data are available, it is possible to evaluate random and purposive sampling strategies using simulations before the start of the study.
The sample size calculations were tested using simulation, to check that they provided the desired power and α, or the desired confidence interval width.
We also investigated the effect of sample size on the different methods, using simulation scenario G, which aims to estimate five parameters (R1, R2, S1, S2, and Ip).
The two spiral sampling techniques are compared using simulations, phantom images, and in vivo brain images.
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