By splitting the Karn579 cohort into those patients with the top tertile DART activation score compared to the remaining samples, the prognostic value of high MaSC for recurrence-free survival (RFS) was highly significant in TNBC when analysed as a categorical variable (hazard ratio (HR) = 2.165; confidence interval (CI) (1.599 to 2.931); P = 5.78e to 07).
Due to the loss of patient information and limitation of sample size, the prognostic value of miR-548q and miR-483-5p miR-483-5p miR-483-5ply evaluated in this study.
We then strictly applied the same method (score or correlation, cutoffs, and scaling methods) as that reported in the original publications to classify each sample into the prognostic group 'low-risk' or 'high-risk'.
In order to confirm that the same clusters were present, we compared the patient groups obtained by direct hierarchical clustering of the 256 FNA samples to the prognostic groups predicted in the FNA samples by the decision tree model derived from the training set (Cohen's κ = 0.70, p < 1E-20).
In addition to the six samples used for SSH, a fresh frozen breast tumour sample set accrued from 1986 to 1998 at the University Medical Centre Muenster served as the source of samples for the prognostic evaluation of differentially expressed genes.
The performance of MammaPrint improved when stratifying patients by ER status, demonstrating highly significant performance in ER-positive samples, whereas, the prognostic significance of the MammaPrint profile in ER-negative patients is questionable.
Studies that focused on the non-operative management of proximal humerus fractures had much smaller sample sizes than the prognostic study designs; despite this, the sample size of non-operative studies was nearly twice as large as the surgical theme publications (median sample size 64.5 vs 35.0, respectively).
In follow-up analyses of the sample of patients, the prognostic value of securin was compared with the established markers of breast cancer proliferation, Ki-67 and mitotic activity index (MAI).
Only one study with a relatively small sample size examined the prognostic value of carotid intima media thickness (CIMT), which is an indicator of vascular morphology rather than function [ 51].
After the first N / 2 subjects were enrolled we tested to see if the sampling distribution of the prognostic factor was different from what was planned for using a one-sample test of the proportion.
