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The small sample, the fact that subjects were self-selected according to bioethics requirements and the catchment throughout local patient associations may limit the generalization of our findings to treatment of less motivated patients.
It is unclear whether the absence of performance deficits in our study reflects the lower severity of obsessive compulsive symptoms in this largely non-clinical sample, the fact that only few of our subjects had a history of anti-depressant medication (in contrast to the studies with patient groups), or a combination.
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Limitations of this pilot study include the enrolment of patients via convenience sampling, the fact that patient outcomes were not monitored beyond hospital discharge and that a risk/benefit analysis was not included in the study design.
Although the biopsies used in our study represent more tissue than is present in FNA samples, the fact that calcified bone tissue is part of these biopsies could potentially have decreased the ability to extract sufficient quality RNA.
However, our finding may also be due to the relatively young age of the sample and the fact that the sample is from Colombo rather than being a national sample.
However, counterbalancing this loss of sample is the fact that ThinPrep samples are significantly less labour intensive than SurePath samples for the processing laboratory.
They did not distinguish between men and women in their study despite the unequal numbers of men and women in their sample and the fact that both samples were taken from highly sex segregated professions.
The study is limited by the small number of participants in our sample and the fact that these were convenience samples at the three study sites.
One advantage of using the planar paper-based samples is the fact that sample preparation and AFM analysis becomes more straightforward compared to the 96-well plate bottoms.
This increase may have been influenced by delay in processing times of the samples, and the fact that samples were checked less often (due to personnel availability), rather than every day.
31P NMR analysis detected no phosphorus compound in the sample, despite the fact that TOPTe is present in the synthesis of CdTe NCs.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com