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This can be explained by the genetic complexity of the disorders and the small sample sizes of certain studies.
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Third, the small sample size of certain subgroups might have contributed to failure in showing migraine as a significant risk factor in the subgroup analyses.
Although this exploratory multicenter study included a large number of ARDS patients, the sample size of certain study groups is small.
Our study was limited by the low response rate and small sample size of certain groups of participants (e.g., healthcare workers and patients with history of psychiatric consultation).
Because we suspected that the sample size of certain racial/ethnic subgroups may have been too small to allow detection of SNP*race/ethnicity interactions, and because the allele frequencies for 13 of the 25 SNPs differed by more than 0.20 between the ethnic groups, we repeated all of our analyses in the subsample of white participants, the largest racial/ethnic subgroup.
Aggregation of this information can allow larger sample sizes for certain rare diseases and is particularly useful for patients with a rare disease [ 7].
Given that some of the pools were generated from different sample sizes of individuals, we expect there to be some level of error associated with certain comparisons.
In NHANES III, certain subgroups of the population were oversampled including Mexican Americans, non-Hispanic blacks and elderly persons to ensure adequate sample sizes of these groups.
20Notice that the small sample size for certain type of transitions could affect the precision of the estimates.
However, given the small sample size of workers in certain occupational groups, only 13 occupational groups were used for the logistic regression analyses.
Despite pooling several years of US data, the sample size for certain nativity/ethnicity and parity combinations was small for some methods, and those results should be interpreted with caution.
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