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Another limitation is that the results of this preliminary study with small sample size necessitate further confirmation in large prospective studies and the functional relevance of the newly identified miRNAs needs to be further clarified.
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While the small sample size necessitates caution regarding conclusions, the correlation between Somali and Oromo populations in CDs and CSDs appears higher than that between Amhara and Oromo or Amhara and Somali (Table 1).
However, the modest sample size necessitates further work, as reflected in the confidence intervals for sensitivity and specificity.
It is important to note that the small sample size, necessitates validation of these candidate gene expression changes in a larger cohort.
Firstly, the small sample size necessitates replication, in order to reproduce the benefits identified in this study of delivering a CBT program via a mobile phone or computer.
Although these studies are of outstanding quality, they each suffer from relatively small sample sizes, necessitating preliminary validation of proposed gene sets.
Alternatively, these differences may be explained by the relatively small sample sizes necessitated by the limited subadult cranial material available in museum collections.
Sample size calculations necessitated 105 cases and 105 controls.
To avoid making a type II error from the results observed, future studies should use a much larger total sample size, possibly necessitating a multicentre approach.
For example, where individual incentives are preferred, small sample sizes may necessitate targeting groups or aggregating scores.
However, increasing the sample size to thousands necessitates additional tagged adaptors leading to preparation of thousands of libraries, which is time consuming and expensive.
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