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All categorical variables were analyzed using the χ2 test, except where small sample size mandated use of the Fisher's exact test.
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The development of the technique now termed high-performance liquid chromatography (HPLC) depended on (1) the development of pumps that would deliver a steady stream of liquid at high pressure to the column to force the liquid through the narrow interstitial channels of the packed columns at reasonable rates, and (2) detectors that would sense the small sample sizes mandated.
Hence, further studies with larger sample size and prospective cohort are mandated to confirm the present findings.
There were limitations to this study including small sample size across different sites, the mandated use of ultrasound in Senegal, and the differences in standard of care at each location.
6– 8, 10– 13 While sample size calculations are almost consistently mandated for single trials, 17 there has been comparatively little discussion of the need for adequate power in a meta-analysis.
For pragmatic reasons (sample size, reasonable expected positive predictive value) and ethical considerations (mandated RHC in all patients) the DETECT algorithm is designed for application in a high-risk SSc population (inclusion criteria DLCO <60% and SSc disease duration >3 years).
The effect of such variation on data quality requires further assessment, in which this would mandate an independent study with sufficient sample size that allows reliable comparison between the data collected by the two approaches.
The small sample size is a limitation in this study and mandates caution when comparing the results with those of other studies.
This represents a moderate effect size [ 28] on which to base our sample size because a smaller effect size, if detected, would be unlikely to mandate significant changes in the healthcare system.
The individual analyses show the time-course of mandate compliance more clearly; the global analysis combines data, enlarges the sample size and smoothes out incidental effects of institutional and timing differences.
Such complexities mandate that study designs be optimised in terms of biopsy quality and sample size.
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CEO of Professional Science Editing for Scientists @ prosciediting.com