In order to reach the statistical power necessary to detect meaningful association, very large sample size is required.
This illustrates that a remarkably large sample size is required to demonstrate the effect of these alleles with reduced penetrance.
The pedicle flap improved some aspects of postoperative pain experience and reduced the incidence of alveolar osteitis, but further investigation with a larger sample size is required to evaluate its significance.
An assessment of the sample size required to detect future SOC changes revealed that at the windthrow sites a similar sample size is required as in the undisturbed reference forest.
A larger sample size is required in order to determine the clinical profile of SP. Predicting whether a patient will have any adverse reactions to general anesthesia is extremely difficult and limited.
However, as only two crows were successful in the mirror group the results are not conclusive and further testing with a larger sample size is required.
However, a large sample size is required to ensure sufficient statistical power to detect genes contributing subtle to moderate effects to phenotypic traits.
Our smaller sample size, restricted age range, and definition of physical activity may explain our divergent finding, although further examination of this relationship with a larger sample size is required.
However, a larger sample size is required to more effectively evaluate whether their distributions when engaged in a spawning aggregation are different (n = 12 coastal, 3 frontal, 6,660 observations, P = 0.06).
Generally, large sample size is required for genetic association studies of single gene and disease susceptibility depending on the prevalence of the implicated polymorphism, since susceptibility of specific disease is always determined by numbers of genes [37].
We conclude that with adjustment of a covariate, GMDR performs better than MDR and a sample size of 1000∼2000 is reasonably large for detecting gene-gene interactions in the range of effect size reported by the current literature; whereas larger sample size is required for more subtle interactions with accuracy<0.56.
