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The minimum new sample size is anticipated to be in the order of 1125 (375 fFN positive and 750 fFN negative women), but the proportions of each will dictate the exact sample size, as it is anticipated that at least 2 fFN negative women are required to achieve the event rate predicted in 1 fFN positive woman.
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Increases in maximum cluster size were anticipated because, as sample sizes increase with time, the number of isolates in each cluster would be expected to increase.
Based on previous investigation [ 7], a large effect size was anticipated, but to use a conservative approach, sample size was calculated using a medium effect size corresponding to a 25% relative increase in postexercise apoptosis.
Group sizes were anticipated to be approximately 10 women.
The target sample size was 850, anticipating a 20% drop out rate, giving an effective sample size of 683 pregnant smokers.
The sample size is 55 genes.
Anticipating on maximum loss to follow-up of 35% and using a non-parametric statistic test (+5%) the calculated target sample size is 370 patients.
Our sample size was lower than anticipated.
Additionally, our sample size was smaller than anticipated, due in part to substantial numbers of clinic patients being ineligible to participate because of language barriers (non-fluent in English) and cognitive dysfunction, and in part to a relatively low acceptance of study participation.
This sample size was selected because it was anticipated that this number would be deemed sufficient in attaining thematic saturation.
Sample size was calculated by anticipating a 6-month improvement in median survival time with respect to the baseline survival in the control group.
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