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Nonetheless, the sample size imbalance between the NT and HT participants is in accordance with the prevalence of chronic hypertension during pregnancy [ 7, 8].
(5) There was a sample size imbalance between the hypertensive and the normotensive groups due to elimination of outliers; 16% of the women that were considered for the fitting of the MAP model were hypertensive, while only 17% were in the PI model.
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Because of a relatively small study sample size, imbalances in baseline characteristics between the treatment groups may have had an impact on our results.
The statistical significance of these differences may speak more to the large sample sizes, imbalance in group sizes, and/or low variability rather than their meaningfulness.
Limitations of this preliminary investigation include a small sample size, some imbalance in the demographic characteristics of the three populations, and a lack of clinical subtyping.
The sample size and imbalance in number between cases and controls was chosen to retain statistical power for our study of K- ras and p53 mutations among cases [80% power to detect odds ratios (ORs) of 2.25 for the exposures of interest].
The high BCVA improvement seen in the 0.5q4 group may be explained by the relatively small sample size and imbalances in baseline disease characteristics (ie, BCVA score and area of CNV).
We used analysis of variance (ANOVA) procedures except where there were unequal sample sizes and imbalance in design; then the GLM procedure was used.
Limited sample size, sex ratio imbalance, pre-adult patients were not included.
We took this conservative analysis approach because of the small sample size and the imbalance between some contrasts (e.g., fewer exposed to DMBA than to vehicle).
If the number and effect on the outcome of prognostic factors is large relative to the total trial sample size, preventing an imbalance might be of greater concern than a trial with few prognostic factors, which has only a modest effect on the outcome and a large sample size.
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