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The resubstitution CoD is the least biased and least variable among all CoD estimators, across the whole range of classifier complexity and sample size considered here, and thus it also displays the best RMS overall.
Notably, the number of studies performed and the sample size considered can also affect the number of genes identified and thus also our interpretations.
This finding is a result of confidence intervals comparison that depends on the sample size considered.
The calculation of sample size considered that a previous pilot study on ECC indicated a prevalence of 22.3%, with a 95% confidence interval and a 5% standard error.
This sample size considered 3 cohorts of patients and assumed a 40% withdrawal rate and a common standard deviation of 0.24 mmol/l.
Nonetheless, our protocol still results in the most similar group in terms of mean expected behaviour, regardless of the sample size considered.
Similar(46)
We have calculated the sample size considering a type I error of 5 and 80% power; however, the sample number is still relatively small.
Several studies have been published for computing sample size considering either a diagnostic test of perfect sensitivity and specificity [ 17], or an imperfect diagnostic test [ 18, 19].
Strengths of the study include the population-based design, the fairly large sample size considering its reliance on blood samples in healthy young individuals, and the availability of a broad panel of CVRFs.
Of the patients, 182 (50.6%) were patients with active psoriasis and 122 (33.9%) had inactive psoriasis, which was in accordance with the initially expected sample size, considering a 10% follow up.
Sample size: considering a rate of ADR-SM possibly not over 1%% of ED patients (personal data), we targeted the enrolment of approximately 5,000 patients (in order to observe a minimum of 30 cases, alpha risk 0.05, power >0.80).
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