In the whole sample, sensitivity was 89.7%, and specificity was 84.1%.
Alternatively, sample sensitivity was scored according to the SI at the highest cytotoxic drug concentration used ex vivo.
In the suicide sample, unweighted sensitivity was 85.2% (95% CI = 73.8-93.0%) in younger patients, and 63.3% (49.9-75.4%) in older patients, and similarly, in the control sample, sensitivity was 60.0% (38.7-78.9%) in younger patients and 48.1% (28.7-68.1%) in older patients.
However, isolation of Brucella spp. is associated with a risk of laboratory-acquired infections and time consuming, and culture sampling sensitivity is often low, depending on the culture medium, Brucella species, disease stage and quantity of circulating bacteria.
The overall per-sample sensitivity was lower than the per-patient sensitivity, but the specificity remained high (Table 3).
Among the 23 studies comparing Xpert and culture done on the same samples, sensitivity was very heterogeneous with a median sensitivity of 0.83 (IQR, 0.68 0.94) whereas specificities were typically very high (median, 0.98; IQR, 0.89 1.00).
If the spring constant of the cantilever is more than 10 times lower or higher than that of the sample, the sensitivity is about 3 times lower, see Figure 6 making the determination of the elastic modulus less accurate.
With such a large sample, the sensitivity is approximately 40% for I > 0.2 and approximately 80% for I > 0.4 (fig. 6 B and F) and the false discovery rate is approximately 30% for I > 0.2 and approximately 50% for I > 0.4 (fig. 6 C and G).
For example, in biopsy samples, the sensitivity is improved from 84.7%to88.2%2% while the specificity is unchanged (91.9%).
For pure samples, the sensitivity is primarily limited by shot noise from the fluorophore and background instead of that from the much brighter excitation source.
