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A sample of the source code implementing the proposed methodological framework, a sample of the dataset used in the case study, and additional results will be available at publication time at the following link https://github.com/riccotti/CustomerTemporalRegularities.

Rousseeuw and Leroy (1987) indicate that robust estimation procedures are essential to identify the most reliable sample of the dataset and these can help identify possible outliers in the estimation model.

We performed Zscore enrichment analysis for KEGG pathways for each sample of the dataset to identify pathways in which genes tend to have significantly higher or lower expression values (Figure 2B).

In bagging, each successive tree is independently constructed using a bootstrap sample of the dataset.

41 43 We repeated the estimation 250 times on a 1% sample of the dataset, randomly drawn without replacement and stratified by the major variables in analysis.

Second, both in Ray et al.'s [1] and Gómez Ravetti and Moscato's [3] studies, some classifiers disagreed with the clinical diagnosis labels on the same samples of the datasets.

This approach requires a re-sampling of the datasets so that majority of the axons appear in the cross-sections.

Random sampling of the datasets and creation of the random genomic positions were performed using custom-made C++ scripts, available upon request (Pjanic et al., 2011).

A randomization procedure is used to compare our approach to the results obtained for samples of the datasets using conventional structural clustering in terms of the proportion of correctly assigned cluster members.

FT-MIR spectra were collected (two replicates on each sample of the calibration datasets, and one replicate on each sample of the validation dataset) as % transmittance in the range of 5012 926 cm−1.

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