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A core collection (N = 21) was also used to test the association between the identified polymorphisms and traits, and this collection contains a representative sample of diversity in cultivated Vitis vinifera L. and in different Vitis species and genera [ 67] (Additional file 10).
Repeating the analysis for all 26 genomes, including CGH results for the 8 additional LIII genomes, reduced the estimate by over 100 genes to 2,330 ± 5, emphasizing the importance of a balanced sample of diversity for estimating core genome size.
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The time-series analyzed in the current study means that the effects of the sampling regime on biased samples of diversity are minimized and an unbiased sample of true genetic diversity is more likely attained [ 20].
They show that the genomes of classical strains are overwhelmingly derived from Mus musculus domesticus whereas wild-derived laboratory strains include a broad sampling of diversity from multiple subspecies with pervasive introgression.
The sampling of diversity is neither random nor representative, and the current list of available genomes reflects particular interests in medically or industrially important pathogens, extremophiles, and organisms with important economic value (e.g., agricultural pests and commensals).
Currently, the dataset with the most extensive sampling of diversity at both var and microsatellite loci within a local population consists of a set of 30 single infection isolates from a local population in Papua New Guinea for which we have sequences for a portion of the var DBLα domain and the alleles for 12 microsatellite loci (Barry et al., 2007; Chen et al., 2011).
We believe that as more target sequences become available, our predicted false negative rates will tend to increase for a given published signature both as a result of better sampling of diversity and as a result of failure to detect newly evolved variants.
Thus they were based on a small sample of taxonomic diversity and diversity within the cystatin superfamily.
This is a small subset of all the NIH-funded research related to the work you want to do, but it is a fair sample of the diversity of androgen-receptor research within NIH.
Chance processes are particularly relevant in smaller populations because of the increased probability of drawing an unrepresentative sample of existing diversity.
The phenotypic evaluation of a small sample of this diversity showed that the tested genotypes exhibited a great deal of root architecture variation (O'Toole and Bland [1987]; Lafitte et al. [2001]).
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