Similarly, no BCRP mutations have been observed in clinical samples of blast cells obtained from leukemia patients [19], [20], [72].
To make sure that they are not coding RNAs, we picked a random sample of them and BLASTed them to see whether they have hits to coding RNA.
The results of the MLPA analysis were summarized in Tables 4 and 5. Deletion of the IKZF1 gene was detected in 2 (3.8%) of 53 patients with available DNA sample of diagnostic leukemic blasts, which was a significantly lower frequency than that of pediatric BCP-ALL patients without TCF3-PBX1 fusion (3.8% vs. 10.4%, P < 0.001, Table 4).
For each hit, there is x proportion of chance that its corresponding organism was assigned to an organism randomly sampled from the pool of BLAST results of all genes.
For each sample, an aliquot of blasts was fixed with 2% PFA at D0 and kept at +4°C in order to maintain the original fluorescence.
To make our analysis tractable, we took a sample of 5000 of these BLAST alignments.
ANb's Frozen Corpse Stuffed with Dope has been described as "the Paul's Boutique of grindcore", by Village Voice critic Phil Freeman, for its "hyper-referential, impossibly dense barrage of samples, blast beats, answering machine messages, and incomprehensibly bellowed rants".
Table 3 shows the results of blast analyses of two samples, TA and HRV16.
In the large-scale selection mode, several tools allow the sampling of homologous sequences among the entire set of BLAST hits (including those that are not shown in the top-100 BLAST subset) using global criterions.
To test the predicted sweet spot, McBride and his team set up an elaborate imaging system that involved blasting a sample of manganese with a high-powered laser (actually a NIF prototype moved to Sandia) to produce x-rays.
