Sentence examples for sample mutations in from inspiring English sources

In the context of early phase drug studies, the type of NGS assay most commonly deployed is one designed to direct patient treatment by detecting tumor sample mutations in dozens to hundreds of cancer-related genes.

In breast cancer samples, mutations in TP53 have been associated with increased incidence of chromosomal abnormalities in patients (86, 87).

For the 110 samples, mutations in all eight genes (EGFR, KRAS, NRAS, MEK1, PIK3CA, BRAF, HER2, and PTEN) were analyzed using the Snapshot assay.

We further investigated possible reasons why canine BRCA2 expression was reduced in tumor samples: mutations in the BRCA2 promoter region and non-sense mRNA decay (NMD) induced by PTCs that can form in splice variants.

One sample had mutations in both exons 7 and 8. Three samples showed mutations in exon 8 only.

One sample showed mutations in both exons.

In sample 1837, mutations in both BRAF and PIK3CA were detected and the BRAF/ PIK3CA ratio was 1.67, but increased to 4.4 in the metastatic lymph node.

In total, 13 of the 38 Barrett's patients were shown to possess a p53 mutation in at least one sample (no mutations in the four control patients).

Samples with a mutation in c108+c59 or c108+c51 of dhfr but no additional mutations were classified as double mutations; samples with mutations in c51+c59+c108 as triple mutations; samples with mutations in c51+c59+c108 of dhfr and c437 of dhps were considered quadruple mutations; and samples with mutations in c51+c59+c108 of dhfr and c437+c540 of dhps as quintuple mutations.

As illustrated in Figure 1b, this decrease was less pronounced from D0 to D7 for samples with RPS19 mutations than for samples with mutations in RPL11.

A second cluster (9 samples) was associated with SHH signaling and 4 samples had mutations in PTCH1 and 1 in SUFU.