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It is also possible that a similar exploration based on a representative population sample might yield different results.
While the findings of this study were completed using a large national sample of African Americans eligible for colorectal cancer screening, it was not representative of a national sample of older African Americans and a representative sample might yield different results.
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Similarly, studies of community based samples might yield fewer adverse events and very different results for individual items.
To determine which pathways govern the early steps of CIN in human carcinogenesis, a comparison of these models to chromosome alterations in tumor samples might yield important clues.
Mutation analysis was carried out on 148 patients for which frozen tissue samples were available, because paraffin-embedded samples might yield a higher proportion of false-positive results (Marchetti et al, 2006; Gallegos Ruiz et al, 2007a), and we avoided using two different sources of samples (frozen and paraffin) for one type of analysis.
One of the weaknesses in our present study is the use of pooled samples for initially global miRNA screening since results generated from pooled samples might yield some inaccurate information and missing useful information due to individual difference, and therefore decreases the specificity of the test.
Higher sample size might yield more accurate results.
A study done for a longer period of time with a larger sample size might yield better results.
A higher sampling rate might yield higher directional resolution.
Since only 7% to 12% of GD individuals seek help for their disorder, a community sample of GD might yield different results.
Combining samples for the last two weeks might yield a statistically significant difference from the average, although it would be close.
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