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Follow-up studies involving a larger sample may allow us to confirm whether changes in myo-inositol associated with acute lithium therapy persist in long-term clinical response of patients with and without lithium compliance.
Newer data, however, suggest a single sample may allow a broad classification of exposure (Meeker et al. 2005).
Subsequent validation in a larger sample may allow the gene underlying this association to be definitively identified.
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Spatial analysis of sampling may allow the detection of under-sampling or over-sampling at the spatial unit of choice.
Oral rinse samples may allow for a more effective collection of oral cells for HPV detection.
A future, larger prospective study with a prolonged sampling may allow to address these issues.
Increased sampling may allow better adjustment to biases along the branches [ 58, 59].
Whole-genome amplification from such samples may allow clarification of the status of such tumours in future.
Tissue samples may allow immunohistochemistry and molecular analysis (e.g. polymerase chain reaction) with special focus on factors indicative for extracellular matrix remodelling and soft tissue calcification [ 8].
The novel monoclonal SOX11-specific antibody offers high sensitivity and improved specificity in IHC-P based detection of MCL and its expanded use in flow cytometry analysis of blood and tissue samples may allow a convenient approach to early diagnosis and follow-up of MCL patients.
In the future, better availability of data from extensive year-round sequence sampling may allow more detailed partitioning of the world population and could help mitigate some of these limitations, as well as improve our estimation of the contribution of different mechanisms in maintaining long-term viral evolution.
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