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However, quality score calibration based on alignments with some divergence to the actual sample is problematic, especially if the divergence to the reference varies between samples.
A more interesting group would be those people who enter hospital in conditions of homeostatic defeat, but how to ethically recruit such a sample is problematic.
However, extrapolating from such a small sample is problematic, especially as other data collected at schools in some of the sampled districts suggests that levels of re-infection are high.
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One in 10 tweets mentioning black women in the study sample was problematic or abusive, compared to one in 15 for white women.
Second, the response rate was insufficient and the representativeness of the sample was problematic.
To determine ethanol in human post-mortem blood samples is problematic, largely due to the inappropriate and variable methods of preserving and storing, which can cause decomposition and loss of alcohol concentration.
Comparing handwriting samples is problematic for several reasons, Denbeaux said, noting that each individual's handwriting fluctuates.
Single molecule observation in large, living samples is problematic.
However, reliable extraction of RNA from archival samples is problematic.
The problem of attrition that can hamper this design is usually recognized, but comparing path estimates based on different samples is problematic as well [ 40].
A separate meta analysis of sensitivity and specificity using the meta analytic tools for independent binomial samples is problematic when the underlying diagnostic test utilizes a continuous or ordered categorical scale and different cut off values have been used in different diagnostic studies.
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