However, the role of liver biopsy as "gold-standard" is subject to increasing debate, owing to possible side effects as well as frequently occurring sampling errors and variability of sample interpretation [ 33].
Herd-level sensitivity (HSe), which is the probability that a seropositive herd is correctly classified as seropositive, is a function of the sample size, diagnostic test sensitivity, sample interpretation and importantly, within herd animal-level prevalence.
Kitchin [2] analyzes that epistemologically BDA is tempted to fall into the traps of empiricism (with bias in sampling, interpretation, etc).
Antibodies Inc. provided the IFA stain used in the study, but otherwise did not participate in or influence the design of the study, handling of samples, interpretation of the data, or the manuscript preparation.
KR, JI: analysis of samples, interpretation of data, manuscript preparation.
KV, study concept and design, coordination and acquisition of samples, interpretation of data, drafting of manuscript.
TS: patient recruitment, collection of samples, interpretation and analysis of data.
ML participated in the recruitment of OA patients, collection of samples, interpretation of data, and reviewed the manuscirpt.
ZJY contributed to collection of test samples, interpretation of the data and critical review of the final manuscript version.
SD performed HRM and Sanger Sequencing of samples, interpretation of pAKT, p4EBP1 and pS6 immunohistochemistry, statistical analysis and manuscript preparation.
