To illustrate this more complex pattern, sample interaction is presented.
In these circumstances a control of beam-sample interactions is no longer a commodity but a necessity.
This may overestimate the sample size requirement, especially if the effect of the interaction is larger than the main effects, but it illustrates the general requirement for a larger sample size when interactions are introduced into hypothesis testing.
The Index of Work Satisfaction measures nurse/doctor interactions and in this sample, these interactions were found satisfying, however the themes 'patients as quasi-family' and 'intense working teams' focus on different relationships.
However, when data were back-weighted to be representative of the entire ARMHS sample, these interactions were no longer significant, indicating that these findings may have been the result of selection effects in our data.
Large numbers of factors are difficult to handle in multivariable models, and require impracticably large sample sizes, especially if interactions are to be modeled.
Thus, while the biology captured by the phenotypes of the gene signatures may be consistent, more than chance alone would predict, between tumour and normal samples, the resultant miRNA-target interactions are significantly different, and miRNA-TSG enrichment is not retained among normal tissue samples, highlighting the strong context dependency of these associations.
Dye-swap experiments were initially performed to assess dye by sample interaction, which was found to be negligible.
We have found experimental conditions for which tip sample interactions are at a sufficiently low level that the intrinsic surface mobility can be studied.
In contrast, in small communities sampling community-wide interactions is more precise.
