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Each sample in a study was normalized using a set of SOMAmers that have the lowest overall relative signal variation across all samples within a study.
Each sample in a study was normalized by aligning the median of each sample to a common reference.
In practice, one ISA-TAB-Nano Material file should be created for each material sample in a study.
The aggregate results are shown in Table 2. Most participants (13/15) agreed they would give a blood sample in a study that would not directly benefit them.
This difference has been demonstrated to account for up to 38% loss of the ThinPrep sample in a study by Bigras et al. 44 These preparatory differences represent a significant technical difference, which laboratories must consider prior to adopting LBC.
This was shown in the Mental Component Summary Score when it was compared with the norm-based score for the same age group in a population sample in a study by Sullivan and colleagues [ 23].
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This highlights the challenge of determining optimal parameters that are usable on a genome-wide scale for all samples in a study.
In general, all of the samples in a study cannot be processed concurrently.
This bacterium was more frequent (66% of samples) in a study in Peru [ 34].
For the second analysis, the reduced dataset included all first samples in a study area, provided that the study area was sampled in the previous month.
Although indeterminate samples did not significantly affect reproducibility, a higher prevalence of indeterminate samples in a study population may prove to be problematic for other populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com