Our resource of a large colorectal cancer sample obtained from two large prospective cohorts (representing a relatively unbiased sample compared to a single-hospital-based sample) has provided a sufficient power to evaluate the 16 methylation markers, and to simultaneously assess independent relations of CIMP-high with multiple clinical and tumoral molecular variables.
The development of RNA-Seq, a method based on NGS which consisting of the direct sequencing of RNA molecules present in a given sample, has provided a new tool for both transcriptome characterization and gene expression profiling.
Recently, random community genomics, or metagenomics, where DNA is sequenced directly from environmental samples has provided insights into microbial communities.
Furthermore, spectral subtraction combined to the van't Hoff relation, already used by O'Reilly and coworkers1,2 for bulk samples, has provided experimental values of the interfacial conformational energy ΔE.
The return of these samples has provided the strongest evidence yet for the long-held idea that the ordinary chondrites, the most common meteorites in our collections, are sourced from the populous S-type asteroids.
The return of the Hayabusa samples has provided us the strongest evidence that the most common meteorites in our collections, the ordinary chondrites, are derived from the S-type asteroids (Nakamura et al. 2011; Thompson et al. 2014).
Application of these probes, alongside available probes targeted to other intestinal bacterial groups, against rRNA extracted from equine colonic samples has provided the first quantitative data on the predominant bacterial populations inhabiting the equine large intestine.
Contemporary in-depth sequencing of environmental samples has provided novel insights into microbial community structures, revealing that their diversity had been previously underestimated.
Our coincident analysis of the microbial and viral sequences that were generated from the microbial fractions of environmental samples has provided us with a unique global perspective on the nature of (primarily) marine virus-host interactions and has stimulated intriguing questions with respect to the evolutionary trajectories of viruses and their hosts.
Environmental sampling has provided evidence of the fungus over a large part of eastern VI.
Within the last 10 years, the establishment of EUS guided fine needle aspiration and lymph node sampling has provided a convenient means by which to establish a cytological diagnosis (Chen and Eloubeidi, 2004).
