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Clinical measurements included a nonfasting blood sample for plasma HbA1c and glucose, serum total and HDL cholesterol, and brachial blood pressures.
Patients were excluded if they took a mixture of brand and generic tacrolimus or failed to leave at least a sample for plasma creatinine within 4 weeks of the conversion.
Subjects taking at least one dose of the study drug for the treatment period; Subjects providing at least one data point (sample) for plasma BPS concentration determination for which information on the date and time of blood collection and medication before the collection is available.
The pharmacokinetics analysis set (PKAS) is defined by subjects fulfilling all of the following criteria: Subjects taking at least one dose of the study drug for the treatment period; Subjects providing at least one data point (sample) for plasma BPS concentration determination for which information on the date and time of blood collection and medication before the collection is available.
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Quantification of uptake may be improved by using blood sampling for plasma radioactivity assessment.
Blood was sampled for plasma concentration determination, and pharmacodynamic endpoint assessments were made during the study.
Semen collections (digital manipulation) were performed twice weekly for 14 weeks and blood samples (for plasma concentrations of cortisol and testosterone) were collected once a week.
Then, we obtained blood samples for plasma catecholamine determination with high pressure liquid chromatography.
A 75 g oral glucose tolerance test (OGTT) was performed with sampling for plasma glucose and insulin.
Blood samples for plasma fasting glucose, total and HDL cholesterol, triglycerides, and creatinine as well as first morning urine specimens to determine albumin creatinine ratio (ACR) were obtained.
Clinic basal BP as in-patient was recorded in the same morning when blood samples for plasma renin activity and aldosterone were drawn (on the day before the salt load).
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