However, because it would require enormous computational resources, one should find a compromise between computational cost and sampling breadth.
More recently, a variation on the mutation-accumulation method has become possible based on phenotype-blind genomic sequencing, which might (or might not) provide improved sampling breadth, usually at the expense of sample size.
These two gene sets (UCOs and shared single copy tribes) represent a highly conserved subset of genes expected to be present in eukaryotic and plant genomes, respectively, and can be used as a proxy for gene detection and sampling breadth.
Furthermore, in striking a balance between privacy and data, it is also important to capture data that encompasses the widest possible demographic to ensure that we are sampling the breadth of samples as to not distort the results.
They were members of the Gastronauts, a dining club for adventurous eaters that travels to the far reaches of New York City to sample the breadth of the world's cuisines.
STRATFORD, Ontario — One of the signal pleasures of attending the Stratford Shakespeare Festival here is the opportunity it affords to sample the breadth and depth of Shakespeare's work in just a few days: a history play on Wednesday, a comedy on Thursday, a late romance on Friday.
Thus, researchers designing RNA-Seq experiments must often determine the correct balance between sequencing depth (the number of reads per sample) and breadth (the number of samples sequenced).
The large sample size, breadth of regions evaluated (every province and major city in Canada), and health outcomes using national-level databases are notable strengths.
Our approach focused on sampling a breadth of species under a range of natural conditions rather than sampling any single species in sufficient depth to take potential causes of intraspecific variation into account.
We devised a data mining agent (i.e., an autonomous software tool), which implements two sampling methodologies (breadth-first search and uniform sampling).
