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Using a relative homogenous samples and a case-control based design, we found that an intronic SNP rs4844285 in NLGN3 gene and a specific 3-marker haplotype block (rs11795613-rs4844285-rs4844286) were associated with ASDs and showed a male bias after multiple correction, which was consistent with the fact that the prevalence rate of ASDs in males is higher than that in females.
For improving the accuracy of surrogate models without significantly increasing computational cost, a rigorous sample selection is employed to reduce additional design samples based on design of experiments over a sequential trust region.
And we could produce the product sample based on the design solution which had been evaluated by models.
The numerical results demonstrate the high level of computational efficiency and excellent computational accuracy by comparison to direct Monte Carlo simulation and original Line Sampling based on design point simulation.
This was a cross-sectional survey of a national sample based on a multistage complex design which has been described in detail previously [ 18, 19].
To prepare the samples, based on the designed plan, each factor was varied in five levels while the other operational parameters affecting the ESR were kept constant (Table 1).
In this work, 27 samples based on Box Behnken design of the experiments were produced using a twin-screw extruder and processing conditions reported in Table 1.
Fig. 1 Prepared ink formulation samples based on the mixture design for the three additives (wax, surfactant, defoamer).
In this work the preparation of porous ceramic samples based on alumina is designed and their properties are characterised by XRD, porosimetry and SEM.
The original study design involved sampling based on calendar months of the typical wet/dry seasons.
Households were sampled based on a multi-stage cluster design.
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