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This is a small sample animal study.
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Our study adds new information combining entire animal, large sample for an animal study, large amounts of chloride, severe and pathophysiologically relevant model of sepsis and renal hemodynamics.
The findings of the laboratory tests warrant further detailed analyses of larger numbers of samples and animal studies to explore the possible toxic effects of these components.
Samples collected in animal study 1 and animal study 2 were prepared and analyzed in November 2009 and May 2010, respectively.
HS carried out the animal study, sample acquisition, histological anaysis and participated in drafting the manuscript.
This two-step strategy was applied to the four samples from the second animal study.
The sample size of the pilot animal study was based on the availability of banked samples.
KSB participated in the animal study and sample axquisition, the molecular genetic study, and in drafting the manuscript.
DGH and DWA coordinated the animal study and sample collection.
The sample size in animal studies of nanosilver cytotoxicity per group varies considerably in literature [35, 36].
Human data shown in this study come from right atrial appendage samples, while the results from animal study are from the ventricle.
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