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Nine different definitions of IIV were computed for each sample, and standardized effect sizes (Cohen's d) were computed for each of these definitions in 500 simulated replicates using scores on the Mini Mental State Exam and Clock Drawing Test.
Expression values were log-transformed, quantile normalized to achieve the same expression value distribution for each sample, and standardized with Z-transformation across the samples.
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More research with large samples and standardized diagnostic interviews is clearly warranted.
These trials, however [ 8– 10], included only 350 women in total and used only 7-day point prevalence of smoking abstinence as a primary outcome, leading authors to recommend replication in more robust designs, using larger samples and standardized assessments of continuous abstinence.
With optimized sample handling and standardized DNA extraction, it is possible to screen paraffin-embedded samples with higher sensitivity [40], [41].
Because it is typically found at very low concentrations in plasma, successful downstream analysis requires prompt sample processing and standardized protocols that can accommodate very small amounts of input material.
Our study benefits from a large, representative sample and a standardized protocol for assessing antibody levels that allows valid comparison with PsA-TT clinical trial results, which were also produced by the same laboratory.
This suggests that the differences between our HRs and the National Diabetes Audit results are attributable to methodological differences (weakness of one-sample design and standardized mortality ratios) rather than underlying differences in the mortality rates between these two large samples from the English population.
We compared mean differences in domain scores for caregivers of RRMS and PMS patients by independent sample t-test and standardized effect size calculations (noting 95% confidence intervals).
The surfaces sampled and the standardized sampling techniques are described in Table 1.
The strengths of this analysis lie in the large database, the probability based sampling, and the standardized methodology of the tri-annual data.
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