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A detailed description of the study design, sample, and exposure measurements has been published elsewhere (7 ).
We first verified that the person selected had not experienced jaundice in the previous 2 years and then collected a blood sample and exposure history using a structured questionnaire.
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Blood sampling and exposure assessments.
The 318 samples and exposure conditions are listed in Table 1.
The second group took a different approach, however, opting instead to utilize human fecal samples and exposure to four different naturally high fiber-containing flours.
The exposed days were defined as exposure level 1 (with detectable brevetoxin levels in air samples) and exposure level 2 (with brevetoxin levels > 10 ng/m in air samples).
Another limitation of this study is that the sampling scheme limited biological samples and exposure measurements to two days in the space of one week, so exposure windows greater than one week and lagged daily exposure effects could not be examined.
Furthermore, in a study among 587 children from families from which occupational exposure to BPA of 93 fathers and 50 mothers was ascertained through personal air sampling and exposure histories, presence of prenatal occupational exposure to BPA was associated with reduced birth weight, especially for maternal occupational exposure (Miao et al. 2011).
One limitation in our application is that SIEVE is designed for controlled studies, with exposure (sample) and non-exposure (control) scenarios in the same matrix.
Indeed, this similarly suggests a robustness of the findings to both sample composition and exposure assignment.
Investigators endeavor to maximize both sample size and exposure potential in selected populations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com