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This study replicates the association between R47H and Alzheimer's disease risk in a large, population-based sample, and estimates the population frequency and attributable risk of this rare variant.
Statistical power issues prevented us from further sub-dividing the sample, and estimates presented are to be regarded as an overall guideline.
Besides the genealogy of the sample, ClonalFrame also infers when and where recombination events took place in the evolutionary history of the sample and estimates population-wide evolutionary parameters (e.g., mutation rate; recombination rate).
Supplementary materials and methods, information for collection locations and data for number of algal nuclei examined in each sample and estimates of nuclear genome size (pg) ± SD are available at http://people.uncw.edu/kapraun/DNA.uncw.edu/kapraun/DNA
Expression data for each sample and estimates of differential expression between sample groups were uploaded through Zenodo at the following address [DOI] (http://dx.doi.org/10.5281/zenodo.12626) and will be available after June 1st 2015 or earlier.
While 30 of the 32 discordant cases were SDQ positive for hyperkinetic disorders in the absence of a clinical diagnosis, this total represents only 6% of the sample, and estimates by parental questionnaires such as the SDQ are known to approximately double the true number of cases in the clinic setting [ 10, 25].
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In this paper, we focus on the latter, where nodes are deployed at fixed positions and cooperate to sample and estimate the event signal.
The distributions of grain sizes were obtained by taking 200 different grain images for the sample and estimating the mean diameters of individual grains by using the imageJ software.
In an analysis of the largest single schizophrenia sample to date, we establish more accurate estimates of risk from individual CNVs in an independent sample, and estimate the total burden of susceptibility conferred by this group of CNVs.
At the matched filter output, the receiver observes N=10,000 samples and estimates the probability density using Fourier inversion method.
Funnel plots and meta-regressions indicate moderate to severe publication bias for all samples and estimates, except for beer income elasticities.
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