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We observed that S/N ratio was >25 during method validation and incurred sample analysis, which was within acceptable limit as per the USFDA/EMEA guidelines.
Note that with finite sample analysis, which will be discussed in the next section, this choice of representation is not that arbitrary and depends on whether n > p.
A rapid rat PK screening paradigm was created by the combination of 1, 4, and 8 h sampling and pooled sample analysis, which improves throughput and cycle time of in vivo PK studies.
The peaks obtained after the sample analysis, which correspond to the (101), (103), (004), (112), (200), (105), (211), (118), (116), and (220) crystal planes, are well indexed to the standard pattern of the anatase phase and also exhibit the crystalline nature of undoped and doped TiO2.
The paired sample analysis, which utilized a small subset of our data comprising only about 10% of all samples, found an increase in the frequency of Yellow in dunes, but not in the other three habitat types (Table 3).
Testing for model differences between groups requires multiple sample analysis, which in the case of gender, for example, would reduce the subsamples to n = 94 and n = 80, providing inadequate power for the number of free parameters in some of the models.
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The recovery of GA in urine, human plasma and water samples within the range of 92.3 100.6% that strongly support high applicability of present method for real samples analysis, which candidate this method as promise for further application.
The analysis time using MALDI-based assays is considerably shorter than using LC-based assays; in this case samples were measured at a speed of 13.5 seconds per sample (triplicate analysis), which is approximately 25 – 100 times faster than the LC-based approaches [2], [29] [31].
Fig. 2 also shows the ratio between the two β-thymosins concentrations in the different samples under analysis, which has a constant value of about 4 in all the range of PMA studied (at-term newborns comprised), except sporadic increases in some pre-term newborns not connected to any evident clinical outcome.
This would arguably eliminate two of our samples from analysis, which we were able to enrich to >90% purity.
Serological surveys for disease investigation of wild animal populations require obtaining blood samples for analysis, which has logistic, ethic and economic difficulties.
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