Table 3 also reports on two sub-samples of the Primary Sample and an Alternative Sample.
To further assess the possible lack of comparability between cases and population samples, an alternative population sample taken directly among GPs usual patients could be used for validation.
However, if the data contain heterogeneous transcriptome from a broad range of samples, an alternative would be more reasonable; module genes are assumed to be co-regulated in only a subset of samples.
Although the sample-independent and -dependent controls can be visually inspected to identify poor performing samples, an alternative approach involves using the raw signal intensities of the control probes and determining whether they are beyond the expected range (e.g., median±3 s.d). of the signal intensities across all samples.
The observed trend has a Pearson correlation of -0.26, which is significant: p = 4.0 e - 2. Of course, since the different datasets have different numbers of samples, an alternative would be to evaluate the correlation of the error and the actual number of samples in the pooled datasets.
Participants who are unable to provide a blood sample may provide a saliva sample as an alternative method of DNA collection (Appendix 1).
Clustered sampling is an alternative sampling approach commonly used to reduce the recruitment effort and gather data from subjects, without reducing the whole population representativeness.
We also estimated models using the principal study sample and an alternative subsample of providers confirmed by the AAOS practice re-survey to have been practicing in the study practices during both study years.
Thus, the significance of these changes needs to be verified from the same sample with an alternative method of measurement that captures the phenotypic changes accompanying driver mutations.
We also compared the suicide risk associated with the treatment groups prior to matching, conducted a Cox regression analysis, and conducted a sensitivity analysis matching the sample with an alternative propensity score.
