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As cancer biologists have long suspected, tumours from the same type of tissue often had different genetic traits, while those from different tissues were frequently similar.
That is tricky because the same type of tissue can have significantly (and unpredictably) different responses to laser light in different patients.It has therefore been impossible to come up with a tissue-welding technique that surgeons can use routinely.
It's the same type of tissue.
Independent biological replicates of RNA samples were created by pooling an equal mass of RNA isolated from the same type of tissue from 4 individuals.
We first computed genotypes for particular tissues based on the most frequent alleles found in all cells from the same type of tissue.
This indicates that the gene expression heterogeneity between adjacent biopsies is similar to that of biopsies farther apart if the biopsies consist of the same type of tissue.
Similar(46)
The heterogeneity of MSCs resident within seemingly the same type of tissues but located in different anatomical areas may be explained by varying local demands for tissue turnover and mechanical loads [48].
One of the goals of this study is to find interacting TFs controlling gene expression in a broad spatial and temporal manner such as interacting TFs common to the same type of tissues.
We further extended our study to find interacting TFs controlling gene expression in a broad spatial and temporal manner by looking for TF pairs common to the same type of tissues, from which TF-TF interaction networks were further built.
To find interacting TFs controlling tissue gene expression in a broad spatial and temporal manner, we extended the analysis to identify tissue TF pairs common to the same type of tissues (referred to tissue-type TF pairs) as well as interactions of 3 TFs.
The analysis process has also led to other findings that the same type of tissues may have significant differences in both the contents of tissue TF pairs and the TF functional roles, which has been demonstrated by the conservation analysis of tissue TF pairs and their functions from muscle tissues.
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