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Interestingly, CCNB1 belongs to the same pathways with CDKN2A and CDKN2B and is regulated by p53.
The seed gene set was expended by including genes having two-level PPI and sharing the same pathways with the seed genes.
We used CANGES to provide the most comprehensive set of proteins that function within the same pathways with p53 or have direct PPI with p53 [Swiss-Prot:P04637, Q9NP68] (Table S2).
The table shows several examples of the same pathways with inconsistent referrals to pathway names in different databases.
Conversely, inhibition of eIF4A1 would be expected to result in 'dampening' of the same pathways with widespread normalizing effects upon the malignant phenotype.
(ii) When merging the same pathways with different levels of emphases in different databases, if we have already merged one detailed-level pathway into a general-level pathway, all other related detailed-level pathways in the databases should be merged into this general-level pathway.
Similar(53)
This suggests that UEV-1 and RAB-10 might function in the same pathway, with the more severe phenotype in uev-1 mutants indicating the possibility that UEV-1 also works in an additional pathway.
These proteins function in the same pathway with PINK1 acting upstream of Parkin.
PINK1 and Parkin function in the same pathway, with PINK1 acting upstream of Parkin.
The propensity for significant complexes to co-localise onto the same pathway with a significant PDS is therefore notably high.
PINK1 and Parkin have been shown to function in the same pathway with PINK1 acting upstream of Parkin (Yang et al, 2006).
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