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Schulman and colleagues [ 12] reported that aggressive fever suppression (acetaminophen administration of greater than 38.5°C and cooling blanket application of greater than 39.5°C) was followed by considerably higher mortality compared with permissive suppression (the same interventions of greater than 40°C, 15.9% versus 2.6%, P = 0.06).
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The secondary aims are to determine the immediate, six and 12-month efficacy of the same intervention on cognitive function and adherence to treatment for CVD.
To determine the influence of methodological quality and homogeneity on the agreement between pairs of randomized trials (RCTs) and nonrandomized studies (NRSs) of the same interventions for low-back problems.
Randomisation is stratified by centre, to avoid imbalance between centres giving different advice in ED, and members of the same household are assigned to the same intervention, to reduce the chance of contamination.
This is a source of heterogeneity across studies comparing the same interventions, and a source of bias in the indirect comparison of treatments [ 29].
The control group were offered the same interventions following the completion of the intervention stage of the study.
The most common flaw is that all trial participants are given the same intervention regardless of classification, an approach contradictory to the principles of McKenzie therapy.
All groups receive the same intervention time of 30 minutes.
The second control arm came from the same intervention area of Cartago and Los Santos.
Previous studies have shown that ICC values are generally higher for variables related to process compared to those for variables related to outcome, since for the same intervention (measure of process), responses may differ between the different individuals under therapeutic management (outcome measurement).
Comparisons of different dosages of the same intervention only, or comparison of the same interventions with different background treatments were excluded.
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