Sentence examples for same conformation for from inspiring English sources

Central to our testing the steric block hypothesis, our 3D structure of the short linker dynein Lis1 complex shows the same conformation for the linker in the presence of Lis1 as we had observed for the full-length linker in the absence of Lis1.

To evaluate the potential utility of SERS for nanopore sequencing of DNA, we first consider a situation where the conformational fluctuations of the molecule are negligible, which, in practice, would correspond to trapping the DNA molecule in the same conformation for each of the translocation steps.

For the tβ3C-receptors, the EC50 value for CGP12177 (−9.66) is within the range of KD values obtained from antagonism of the more efficacious agonists (−9.11 to −9.94) suggesting that CGP12177 is a typical partial agonist causing its stimulation and antagonism by occupying the same conformation of the receptor (which is also the same conformation occupied by the other agonists).

They need not exist in the same conformation, and conformational changes are not propagated to all subunits, thereby providing the possibility for a hybrid TR form to occur.

JZL184 might not be able to enter the narrower cavity of bMGL or bMGL might not be able to accommodate the two aromatic substituents of the inhibitor JZL184 in the same conformation as observed for SAR629 in the human structure.

To further understand the structural basis for selectivity, we determined the crystal structure of CpOGA in complex with GlcNAcstatin D. These data show that GlcNAcstatin D binds deep into the active site of CpOGA, with the sugar moiety adopting a E conformation, and assuming the same conformation as observed for the GlcNAcstatin C complex [ 41].

The peptide bond of Asp297 Asp298 is in the same conformation as described for the apo structure [24] and the STZ-liganded structure [31], thus the backbone carbonyl from Asp297 points into the active site and the side chain of Asp298 points out of the active site.

The X-ray structure of 4 was used a starting point in the geometry optimization of 1tr to avoid time-consuming conformational searches, and the same conformation was used in the calculations for 1tts and 1tp.

Native VLPs like the ones we have produced allow the viral proteins to be presented to the immune system in the same conformation as in the virion for effective B and T cell response [31].

In the metal-bound form of cADO, there is insufficient space available within the hydrophobic cavity for compound 1 to bind in the same conformation as stearate.

Unlike the uncomplexed TmPurL structures, in StPurL the loop corresponding to residues 360−390 adopts the same conformation as that in the TmPurLQS complex, confirming the importance of this particular loop conformation for the complex formation.