In general, the same small aberrations as well as large gains were seen in both MIN-Os and tumors, suggesting that these genomic changes were already present in the MIN-Os.
12– 22 Reprogrammed sarcoma and glioblastoma cells retain the same genomic aberrations as parental cells and can differentiate into multiple lineages.
Because normal cells do not possess the same metabolic aberrations as metastatic CRPC cells, SIM+MET treatment had only a minimal effect on normal prostate epithelial cell viability, ~5% decrease in viability at the top-end of the pharmacological range.
Although LCIS shares many of the same genetic aberrations as ILC, suggesting that it is a precursor lesion, it is also a risk factor for developing invasive cancer in the contralateral breast (Fisher et al, 2004).
As microvascular endothelial cells may exhibit the same genetic aberrations as tumour cells (Gunsilius, 2003; Hida et al, 2004; Streubel et al, 2004), we first analysed whether the tumour vasculature in ACN/neo and ACN/IFN-γ xenografts contained tumour-derived endothelial cells.
Since our goal was to find duplications and deletions that were de novo, a criterion for selection of CNVs for further analysis was that the child have the same aberration with each parent as reference.
The individual eye model has the same wavefront aberration as that measured from Hartmann Shack wavefront sensor.
Two of these were an aberration, as well -- the two-month "Bin Laden bounce" he got last spring.
The same chromosomal aberrations were detected at the level of large-scale structural aberrations (e.g. chromosomal loss) as well as at the level of more focal events (high level amplifications and homozygous deletions) (Fig. 1b, additional examples on supplementary Fig. 2b).
Cells were considered as a clone when at least two had the same structural aberration or trisomy, or at least three had the same monosomy [9].
