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Multivariate analysis confirmed the salvage intent (β = 1.4910, SE = 0.8494, P = 0.08) and LN risk involvement (β = 0.0210, SE = 0.0093, P = 0.01) as prognostic factors for biochemical relapse.
The number of patients was very limited and the patient population was not homogeneous because of different clinical backgrounds, and they received CRT with salvage intent.
The strategy of using chemotherapy alone as a primary treatment for LAPC, followed-by CRT for salvage intent, should be further investigated in prospective clinical trials.
The strategy of using chemotherapy alone as a primary treatment for LAPC, followed-by CRT with salvage intent should be further investigated in prospective clinical trials.
The lymphoscintigraphy and sentinel lymph-nodes identification has strengthened the prognostic and therapeutic value of the extended pelvic LN dissection (ELD), stressing the importance of large irradiation fields and techniques that allow to safely administer high doses, and support the use of pelvic irradiation after a RP with SLD, both with adjuvant and salvage intent.
Similar(54)
In our study, all patients were treated with SBRT for small viable HCC as the salvage treatment intent after undergoing several previous severe treatments, namely transarterial chemoembolization, hepatectomy, and/or RFA.
Methods: Men being considered for curative-intent salvage therapy following first BCR were recruited at 6 UK sites.
Disease-specific survival (DSS) was defined as surviving the protocol treatment and having no evidence of distant metastases, nodal recurrence or local recurrence within the bladder that could not be salvaged with curative intent.
Of 993 patients of the RP group, 253 patients (25%) had biochemical failure, of whom 48 patients received salvage RT with curative intent in our center.
Local salvage therapies with curative intent include additional irradiation of the prostate, RP, and other new treatment options such as cryosurgery, transrectal high-intensity focused US, photodynamic therapy and radiofrequency interstitial, and microwave thermoablation [ 72].
Reviews of the relatively small number of trials comparing two or more specific follow-up strategies have suggested that more intensive strategies tend to increase survival at five years, detecting recurrence about six months earlier than less intensive strategies [ 6- 8] at a point where salvage surgery with curative intent is more likely to occur (10.7% vs. 5.7%; p = .0002) [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com