We used Random Forests and Partial Least Squares Discriminant Analysis to select the most salient impairments in Developmental Coordination Disorder (DCD) and assess patients similarity.
Damage to the right IPL leads to deficits in both maintaining attention and also responding to salient events, impairments that contribute to hemineglect, the classical syndrome that follows lesions of this region.
Given the high cost and complexity of prospective, longitudinal investigations, cross-sectional pilot studies focusing on highly exposed individuals can be valuable for the initial identification of salient domains of impairment.
Vision impairments are highly salient and disabling so that older people may seek medical help more easily for these than for other ageing-related health problems.
A salient effect of ethanol is cognitive impairment [5], [19], which may account for the disinhibited courtship of sexually aroused males under the influence of ethanol.
The auditory deficits in these cases have not been systematically characterized; however, the available evidence suggests that most have a clinical syndrome aligned with PNFA, comprising speech production failure with variably salient accompanying features, including dysprosody, dysarthria, working memory impairment, parietal signs and behavioural disturbance.
It may be, though, that the physical, sensory, or psychic experience of a particular impairment turns out to be central and salient to how those with the impairment live – even in a society deeply committed to inclusion, participation, and non-discrimination.
Its most salient phenotypes comprise severe growth delay, neurological defects, cognitive impairment, skeletal and cardiac anomalies.
Disease severity, comorbidities, and impairment of activities of daily living are salient prognostic factors [ 3, 5, 6].
Future research needs to address whether changes in the motivation to communicate are due to impairment in the recognition of others as salient stimuli or a specific reduction in the motivation to interact.
