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On half the trials, the decoy was less salient than the target (target salient condition) and on the other half, the target was less salient (decoy salient condition).
In the salient condition, the central object in the array was perceptually distinct from all others (Figure 1, left panel), and in the non-salient condition, a non-distinctive object was used instead (Figure 1, right panel).
Similar to previous experiments, the results show a marked effect of coherence and duration, and performance improved with increasing salience of the figures with listeners reaching hit rates of 89 ± 5% for the most salient condition.
We further investigated whether the superiority of the dual-route model was specific to the maximally salient condition (unpredictable sounds in the context of a fearful face) or common to all conditions.
The results show good behavioral performance (maximum hit rate of 0.93 was obtained for the most salient condition) which varied parametrically with the coherence and duration of the figure.
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The models developed here are not, actually, linked to this particular scenario, which we adapt for the sake of concreteness; however, co-selected ensembles of RNA molecules and some form of compartmentalization are salient conditions.
The salient conditions were: Advion Nanomate 'A' chip set at -2.1 kV with zero PSI head pressure, resulting in a flow rate of approximately 300 nl/min, and the ICR set to attain a resolution of 200,000 (at m/z 400, 10% valley definition).
These analyses were important for interpreting differences between trials with first saccades to the target versus distractor in the distractor-salient condition.
Comparing groups 3 and 4 on the non-salient condition only, whereas the distance between the object pairs was the same, RT was significantly faster in group 3 in which the object pair contained the central object (mean difference = 528.8 ms, t(19) = 5.78, p<.001).
A similar but reduced pattern is seen for target-salient conditions.
In other words, the behavioral decrement (in terms of the reduced effect of salience on performance) can potentially be explained by the fact that a relative prefrontal deactivation that occurs in the salient reversal condition on placebo is also seen to occur in the null reversal condition on l-dopa.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com