Still, Chanel, with its array of tweedy clothes, quilted handbags and fruitful fragrances that approach $5 billion in annual sales, was considered the paradigm of luxury brands, so its retrenchment is seen as especially ominous.
In my opinion, multiple reasons include, but are not limited to, higher efficacy, faster decline in HCV RNA in the first four weeks, lower pill burden, better dosing regimen, simpler treatment paradigm, experienced sales force and account managers, good patient copay support, and a great scientific story.
The classic OEM business model – with its dependence on turnover generated from new vehicle sales – is undergoing a major paradigm shift as value creation returns continue to fall.
Both are held up as paradigms of enterprise sales, and are often highlighted as examples of how it's always been done (and presumably, always will be).
These disruptive systems are essentially trying to change the traditional paradigm for Point Of Sale purchases.
Proponents of a "New Paradigm" for valuation argued that sales, not earnings, would drive stock prices.
Storytelling, we found, was a much more effective way of communicating in this new paradigm than pithy slogans or sales pitches.
Eventbrite CEO and Co-Founder Kevin Hartz explains, "At The Door transforms an off-the-shelf iPad into a paradigm-shifting tool for managing sales for events.
The head of sales at the time characterized it as "a true paradigm shift in contracts and language". It was indeed.
