To design so that a specified level of safety is reached and then maintained in service by a complementing risk management process.
This important safety milestone was reached on Monday 27 October 2014..
Previously, we demonstrated in a phase I study that a relevant systemic exposure of oral paclitaxel, with a good safety profile, was reached at the dose level of 90 mg m−2 twice on one day each week (Malingre et al, 2001a).
The skin temperature was recorded and the probe was heated at a constant rate of 0.6°C per second until the dog reacted to the thermal stimulus or the safety cut-out of 55°C was reached.
"The pros and cons of having public access to the track were carefully considered and ultimately, consensus was reached that student safety is our first priority," she said.
There is no safety to be reached.
At about the same time, the International Energy Agency reported that, with rapidly increasing carbon emissions from fossil fuel use, the limit of safety will be reached by 2017, if the world continues on its present course.
Results show that the greatest safety margins are reached when the tokamak is supported through the lower ports rather than the equatorial ports, though all analyzed configurations are compliant with RCC-MRx design rules.
The staff's technical conclusions regarding potential safety benefits were reached before considering potential costs.
But it is important to remember that today's new normal state of near-absolute airline safety has been reached at a very high cost.
At about the same time, the International Energy Agency reported that, with rapidly increasing carbon emissions from fossil fuel use, the limit of safety will be reached by 2017 if the world continues on its present course.
