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The learned safety paradigm as a mouse model for neuropsychiatric research.
"Changing the Patient Safety Paradigm". Stevens, Jennifer, Retsef Levi, and Kenneth Sands.
Stevens, JP, Levi, R, Sands, K. Changing the patient safety paradigm.
miR-132 KO and wildtype littermate controls (WT) were subjected to the learned safety paradigm and the performance in the recall test was evaluated.
Similar to learned fear, the learned safety paradigm can be examined experimentally in humans as well as in animals, including rodents1,6.
In contrast, in the learned safety paradigm, CS and US are always presented unpaired, and therefore the CS is perceived as a signal of safety, indicating protection from imminent danger1.
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Earthquake safety paradigms in urban scenarios can be represented by the following: buildings response to ground shaking; possibility to evacuate urban areas; rescuers' assistance to evacuating pedestrians after reaching assembly points in the urban fabric.
1. Responsibility is oriented to the future: the specific approach of RRI does not aim only at sanctioning, compensating or preventing the negative consequences of innovation, like the fault, risk and safety paradigms did, respectively.
Learning from incidents in health care is based on the traditional safety-engineering paradigm, where safety is defined by the absence of negative events (Safety-I).
Resilience engineering (RE) has been advocated as a new safety management paradigm, compatible with the nature of complex socio-technical systems.
As these correlations between epigenetic changes and toxicity are made, the natural next question is if the current safety assessment paradigm utilizing a no-observed-adverse-effect level (NOAEL) is protective of public health for an epigenetic mechanism.
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