Sentence examples for safety of initial from inspiring English sources

The ATAC trial was originally designed to determine the efficacy and safety of initial adjuvant anastrozole (n = 3125), tamoxifen (n = 3116), or the two agents in combination (n = 3125) in PMW with early breast cancer.

NVP being the NNRTI of choice in Democratic Republic of Congo (DRC) in 2008, the Lubumbashi trial was designed to assess the efficacy and safety of initial ART with NVP compared with lopinavir/ritonavir (LPV/r) with two backbones recommended by WHO, either tenofovir disoproxyl fumarate/emtricitabine (TDF/FTC) or zidovudine/lamivudine (ZDV/3TC).

The present trial investigated the feasibility and safety of an initial enhanced recovery after surgery (ERAS) path for patients undergoing robotic beating-heart TECAB and compared it with both conventional surgery and traditional perioperative care.

A predetermined interim assessment was performed to evaluate the efficacy and safety of the initial LY2605541 dose conversion and its impact on the two algorithms.

Recognizing this gap in current knowledge, we evaluated the efficacy and safety of utilizing initial therapy with IV anidulafungin, followed by an optional early step-down to oral fluconazole or voriconazole for the treatment of C/IC in adults.

The aim of this study was to evaluate the efficacy and safety of an initial combination treatment with saxagliptin plus metformin and compare it to a saxagliptin- or metformin monotherapy in treatment-naïve patients with type 2 diabetes and inadequate glycemic control.

28 The safety and efficacy of initial combination therapy with linagliptin and pioglitazone (30 mg) was investigated in 389 T2DM patients (pioglitazone + linagliptin, n = 259, pioglitazone + placebo = 130).

Feasibility testing : These are pilot studies whose objectives include, among others, early characterization of safety and initial proof of concept in a small specific patient population (in vito or in vivo testing).

Upon satisfactory evaluation of safety and initial evidence of antitumor activity, an additional 35 evaluable patients were enrolled.

Therefore, this noninterventional study assessed the efficacy and safety of everolimus after initial VEGF-targeted therapy in patients with mRCC in the routine clinical setting in Germany.

The aim of this prospective, noninterventional, observational study was to assess efficacy and safety of everolimus after initial VEGF-targeted treatment in patients with metastatic renal cell carcinoma (mRCC) in routine clinical settings.