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The factors of safety obtained from 2D slope stability analyses are not necessarily more conservative than 3D slope stability analyses.
Factors of safety obtained with Terzaghi (1943) limit equilibrium model are shown to be both conservative and non-conservative depending on the combination of input values considered for the model.
The global factor of safety obtained using the shear strength reduction technique is used as the criterion for the ultimate limit state and the calculated percent strain around the opening is adopted as the serviceability limit state criterion.
The 2D and 3D slope stability analyses on the slope that failed in 1989 showed that the average shear strength parameters of the residual soils are representative of the slope and the factors of safety obtained from 2D slope stability analyses are not necessarily more conservative than 3D slope stability analyses.
With reference to some of the designs by the engineers in Hong Kong, the authors will also demonstrated that the minimum factors of safety obtained by the current design practice may be over-estimated due to the convergence problem in the stability analysis.
After every third patient that finished the first 30 days period of the study, the monitoring board will receive data on efficacy and safety obtained from the patients.
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The focus on this application is the degree of consistency of the safety impacts obtained from the two calibrated safety models rather than on the variable speed limit sign system itself.
The study safety officer reviewed all relevant safety data obtained from the study sites.
The good efficacy of tocilizumab was accompanied by a manageable safety profile, which was in accordance with the safety data obtained during the clinical development programme of tocilizumab.
Even if the conclusion of safety was obtained in early exploratory studies, the verification study must also carefully evaluate safety through the monitoring of appropriate subjects.
Such safety data obtained from clinical trials are usually sufficient, but further close monitoring of clinical safety of the biosimilar product is usually needed in the postmarketing period.
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