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The safety hypothesis for a trial combining pioglitazone with dapagliflozin would not be anticipated to worsen the pioglitazone-related side effects and, because dapagliflozin causes glucosuria, which drives diuresis and caloric loss, it may mitigate the concerns of weight gain and fluid retention/edema.
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According to this "safety assurance" hypothesis, the signalling behaviour of male wrasse conveys information about the safety of the site.
Rejection of the proof-of-safety null-hypothesis may then be interpreted as an indication of acceptable metabolite levels.
These results may reflect the "safety in numbers" hypothesis or cyclist preference towards safer intersections and corridors.
The results suggest more cautious approaches may be necessary for designing urban spaces for walkability and also call into question prescriptions based on the "safety in numbers" hypothesis.
Monitoring GI symptoms in SYNERGY has two purposes, safety monitoring and hypothesis generation.
To test the hypothesis that safety, efficacy, and image quality in pediatric patients who undergo deep sedation for cardiac magnetic resonance imaging (CMR) for congenital heart disease (CHD) is similar to general anesthesia (GA).
For the secondary hypothesis of safety in our double blind sham controlled trial with 20 subjects in each group, we examined a recent single blind randomized controlled trial of BoNT-A in children with bilateral CP [ 32].
Furthermore, data provided by several studies involving a combined regimen of cetuximab and irinotecan support the hypothesis that safety and efficacy of a biweekly schedule are similar to a weekly schedule [ 15– 17].
Descriptive studies, including case reports, case series, cross-sectional, and ecologic studies, help identify potential safety signals and generate hypotheses.
The aim of the study was to test the hypothesis that patient safety culture is a local phenomenon, implying that patient safety culture scores vary considerably by hospital department and ward, and that much of the variation is across the lowest level organizational units: the wards.
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CEO of Professional Science Editing for Scientists @ prosciediting.com